Morphinan derivatives with an oxabicyclo [3.2. 1] octane structure as dual agonists toward δ and κ opioid receptors
Y Uenohara, S Tsumura, S Hirayama, E Higashi… - Bioorganic & Medicinal …, 2022 - Elsevier
… Herein, we report an attempt to design and synthesize novel KOR … Synthesis of new opioid
derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic …
derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic …
Isolation, biosynthesis, and chemical syntheses of the hasubanan and acutumine alkaloids: A historical perspective
DC Grünenfelder, SE Reisman, R Navarro - Tetrahedron, 2023 - Elsevier
… skeletal rearrangement of 17 to 5 has not been validated in a biosynthetic context, researchers
have successfully converted a morphine derivative to a propellane … affords pentacycle …
have successfully converted a morphine derivative to a propellane … affords pentacycle …
New small-molecule analgesics
SS Laev, NF Salakhutdinov - Current Medicinal Chemistry, 2021 - ingentaconnect.com
… Aside from position 14 of the morphinan skeleton, the N-substituent also plays an important
role in opioid activities and, thus, new … Pentacyclic propellane derivatives were designed and …
role in opioid activities and, thus, new … Pentacyclic propellane derivatives were designed and …
Enantioselective Total Synthesis of (+)-Stephadiamine
B Yang, G Li, Q Wang, J Zhu - Journal of the American Chemical …, 2023 - ACS Publications
… as its 4-bromobenzoylated derivative. Different from the parent hasubanan alkaloids, this
pentacyclic alkaloid contains an aza[4.3.3]propellane … [4.3.3]propellane skeleton. (16) Based on …
pentacyclic alkaloid contains an aza[4.3.3]propellane … [4.3.3]propellane skeleton. (16) Based on …
A synthesis of oxo-thioxo [3.3. 3] propellanes from dithiocarbamates and ninhydrin–malononitrile adduct
I Yavari, A Khajeh-Khezri - Molecular Diversity, 2017 - Springer
… and regioselective synthesis of oxo-thioxo[3.3.3]propellanes by one-pot three-… new
bonds in a single operation, which makes it an attractive method for the synthesis of [3.3.3]propellane …
bonds in a single operation, which makes it an attractive method for the synthesis of [3.3.3]propellane …